Model of the systemic lupus erythematosus pathogenesis based on an autoimmune response to mitochondrial components

Bicytopenia Secondary to Autoimmune Myelofibrosis as the First Presentation of an Undiagnosed Systemic Lupus Erythematosus: A Rare Case Report

Autoimmune myelofibrosis (AIMF) is considered as an infrequent cause of bone marrow fibrosis (BMF) and a rare complication of systemic lupus erythematosus (SLE). Due to its rarity, it is mistakenly diagnosed as primary myelofibrosis (MF). We describe the clinicopathologic features of a secondary form of AIMF in a 33- year- old female patient with an undiagnosed SLE which presented with acute b...

Systemic lupus erythematosus--an autoimmune disease?

The discovery of the LE cell phenomenon by Hargreaves in 1948, quickly followed by the elucidation of its immunological mechanism (Haserick et al., 1950; Miescher and Fauconnet, 1954), proved to be the curtain-raiser that demonstrated the diagnostic relevance of an undoubtedly autoimmune curiosity, and set the stage for the longrunning drama relating autoimmunity to connective tissue disease wh...

Pathogenesis of systemic lupus erythematosus.

The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved. Multiple genes contribute to disease susceptibility. The interaction of sex, hormonal milieu, and the hypothalamo-pituitary-adrenal axis modifies this susceptibility and the clinical express...

Neurobrucellosis in systemic lupus erythematosus

Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...

Poorly understood pathogenesis of Systemic Lupus Erythematosus